Built in the first half of the 16th century as a vote of the town, freed from the plague and locusts in 1526. The sandstone portal with the municipal coat of arms in the tympanum is the work of M. Giacomo da Varese (1569). The one-nave interior was renovated and adorned with beautiful stucco friezes in 1647. The wooden side altars (17th century) come from the Church of the Magdalene: the one on the right is dedicated to St. Joseph, the one on the left to St. Roch, titular of the church, whose wooden statue is attributed to the Ripan sculptor and painter Don Francesco Evangelisti (sec. XVII), to whom are also attributed the two small statues (also from the Magdalene) of a Franciscan saint (to the right of the high altar) and St. James of the Marches (in the sacristy); the altar statue, the Sacred Heart of Jesus (c. 1875), is the work of Ascoli sculptor Giorgio Paci; the bronze Crucifix at the side of the altar (1970s) is by sculptor Ubaldo Ferretti. The small liturgical organ was made in 1780 by Domenico and Francesco di Verrucchio. In the sacristy are preserved: about thirty "pieces" of an artistic nativity scene in painted terracotta, transferred here in 1810 from the church of the Maddalena; the Pietà, a polychrome sculptural group; three canvases painted by Giuseppe Gramacci from Ripano (17th-19th centuries): St. Jacinta Marescotti, St. Raniero (protectors of the Confraternity of the Sacred Heart known as the Sacconi, which has its headquarters in the church), St. Leonard.